Condition
Advanced Pleural Malignant Mesothelioma|HLA-A*0201 Positive Cells Present|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Pleural Malignant Mesothelioma|Stage III Non-Small Cell Lung Cancer|Stage III Pleural Mesothelioma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Pleural Mesothelioma
Estimated Enrollment: 20
Age Group: 18 Years and older (Adult, Senior)
Gender: All
Study Type: Interventional
Study Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: Treatment
Study ID Numbers: 2727.00|NCI-2015-00329|2727|P30CA015704
Study First Received: March 31, 2015
Last Updated: January 4, 2017
Estimated Primary Completion Date: June 2017
Primary Outcome Measures:
Evidence and nature of toxicity based on the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0|Feasibility of naive T cell (TN) and central memory T cell (TCM) subsets, measured as the proportion of patients for which T cells are successfully generated and infused and whether only TN or TCM could be generated|Persistence of transduced T cells|Frequency of transferred T cells at biopsied tumor sites between the Tn and Tcm groups|Functional capacity of transferred cells, measured by production of intracellular cytokines|TTP based on RECIST criteria and immune-related response criteria
Sponsors and Collaborators:
Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)
Website Link: https://ClinicalTrials.gov/show/NCT02408016
